ENTRY       EC 4.1.1.22
NAME        Histidine decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     L-Histidine carboxy-lyase
REACTION    L-Histidine = Histamine + CO2
SUBSTRATE   L-Histidine
PRODUCT     Histamine
            CO2
COFACTOR    Pyridoxal phosphate
            Pyruvate
COMMENT     A pyridoxal-phosphate protein (in aminal tissues). The bacterial
            enzyme has a pyruvoyl residue as prosthetic group.
PATHWAY     PATH: MAP00340  Histidine metabolism
DISEASE     MIM: 142704  Histidine decarboxylase
MOTIF       PS: PS00392  S-[LIVMFYW]-x(5)-K-[LIVMFYWG](2)-x(3)-[LIVMFYW]-x-[CA]-
                         x(2)-[LIVMFYW]-x(2)-[RK]
GENES       HSA: HDC(Hs.1481)
STRUCTURES  PDB: 1PYA  
DBLINKS     University of Geneva ENZYME DATA BANK: 4.1.1.22
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.22
            SCOP (Structural Classificaion of Proteins): 4.1.1.22
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