ENTRY       EC 3.6.1.9
NAME        Nucleotide pyrophosphatase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     Dinucleotide nucleotidohydrolase
REACTION    a Dinucleotide + H2O = 2 Mononucleotide
SUBSTRATE   Dinucleotide
            H2O
            NAD+
            NADP+
            FAD
            CoA
            ATP
            ADP
PRODUCT     Mononucleotide
            AMP
            NMN
            AMP 2'-phosphate
            FMN
            AMP 3'-phosphate
            D-Pantetheine 4'-phosphate
            Pyrophosphate
            Orthophosphate
COMMENT     Substrates include NAD+, NADP+, FAD, CoA and also ATP and ADP.
PATHWAY     PATH: MAP00230  Purine metabolism
            PATH: MAP00500  Starch and sucrose metabolism
            PATH: MAP00740  Riboflavin metabolism
            PATH: MAP00760  Nicotinate and nicotinamide metabolism
            PATH: MAP00770  Pantothenate and CoA biosynthesis
DISEASE     MIM: 173335  Phosphodiesterase I/nucleotide pyrophosphatase 1
                         (homologous to mouse
MOTIF       PS: PS00524  C-x-C-x(3)-C-x(5)-C-C-x-[DN]-[FY]-x(3)-C
GENES       HSA: PDNP1(M6S1) PDNP2(ATX) PDNP3(PD-IBETA)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.6.1.9
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.9
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