ENTRY       EC 3.6.1.38
NAME        Ca2+-transporting ATPase
            Calcium pump
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     ATP phosphohydrolase (Ca2+ -transporting)
REACTION    ATP + H2O = ADP + Orthophosphate
SUBSTRATE   ATP
            H2O
PRODUCT     ADP
            Orthophosphate
COFACTOR    Ca2+
            Vanadate
COMMENT     Hydrolysis of ATP is coupled with the transport of Ca2+ ions.
            The enzyme from the plasma membrane of eucaryotes differs from
            that found in sarcoplasmic reticulum in that it is activated by
            calmodulin, is sensitive to low concentrations of vanadate, and
            is of higher molecular mass (150 kDa). Formerly included with
            EC 3.6.1.3.
DISEASE     MIM: 108731  ATPase, Ca++ transporting, plasma membrane, 1
            MIM: 108732  ATPase, Ca++ transporting, plasma membrane, 4
            MIM: 108733  ATPase, Ca++ transporting, plasma membrane, 2
            MIM: 108740  ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2
            MIM: 300014  ATPase, Ca++ transporting, plasma membrane 3
MOTIF       PS: PS00154  D-K-T-G-T-[LIVM]-[TI]
GENES       SYN: sll0672(pacL)
            SCE: YAL026C(PMC1) YDR093W(DRS2) YER166W(SYGP-ORF7) YGL006W(PCA1)
                 YGL167C(PMR1)
            HSA: ATP2A1(ATP2A) ATP2A2(ATP2B) ATP2B2(PMCA2) ATP2B3(PMCA3)
                 ATP2B4(PMCA4)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.6.1.38
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.38
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