ENTRY       EC 3.6.1.37
NAME        Na+/K+-exchanging ATPase
            Sodium pump
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     ATP phosphohydrolase (Na+/K+ -transporting)
REACTION    ATP + H2O = ADP + Orthophosphate
SUBSTRATE   ATP
            H2O
PRODUCT     ADP
            Orthophosphate
COFACTOR    Na+
            K+
INHIBITOR   Ouabain
            GTP-gamma-S
COMMENT     An enzyme from the plasma membrane of animal cells. Hydrolysis
            of ATP is coupled with the exchange of Na+ and K+ ions, and
            is specifically inhibited by ouabain. Formerly included with
            EC 3.6.1.3.
            Also inhibited by GTP-gamma-S (D.L.McGill (1991) Biochemistry
            30, 6727-6734).
DISEASE     MIM: 182310  ATPase, Na+K+ transporting, alpha-1 polypeptide
            MIM: 182330  ATPase, Na+K+ transporting, beta-1 polypeptide
            MIM: 182331  ATPase, Na+K+ transporting, beta-2 polypeptide
            MIM: 182340  ATPase, Na+K+ transporting, alpha-2 polypeptide
            MIM: 182350  ATPase, Na+K+ transporting, alpha-3 polypeptide
MOTIF       PS: PS00152  P-[SAP]-[IV]-[DNH]-x(3)-S-x-S
            PS: PS00153  [IV]-T-x-E-x(2)-[DE]-x(3)-G-A-x-[SAKR]
            PS: PS00154  D-K-T-G-T-[LIVM]-[TI]
            PS: PS00389  [LIVM]-x-[LIVMFYT]-x(3)-[LIVMT]-[DENQK]-x(2)-[LIVM]-x-
                         [GSA]-G-[LIVMFYGA]-x-[LIVM]-[KRHEQ]-x-[GSEN]
            PS: PS00390  [FYW]-x(2)-[FYW]-x-[FYW]-[DN]-x(6)-[LIVM]-G-R-T-x(3)-W
            PS: PS00391  [RK]-x(2)-C-[RKQW]-x(5)-L-x(2)-C-[SA]-G
            PS: PS00449  [STAGN]-x-[STAG]-[LIVMF]-R-L-x-[SAGV]-N-[LIVM]
            PS: PS00605  [GSTA]-R-[NQ]-P-x(10)-[LIVMFYW](2)-x(3)-[LIVMFYW]-x-
                         [DE]
GENES       HSA: ATP1A1 ATP1A2 ATP1A3 ATP1B1(Hs.78629) ATP1B2(Hs.90792)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.6.1.37
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.37
///