ENTRY       EC 3.6.1.36
NAME        H+/K+-exchanging ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     ATP phosphohydrolase (H+/K+ -transporting)
REACTION    ATP + H2O = ADP + Orthophosphate
SUBSTRATE   ATP
            H2O
PRODUCT     ADP
            Orthophosphate
COFACTOR    H+
            K+
COMMENT     So far characterized only in gastric mucosa. Hydrolysis of ATP
            is coupled with the exchange of H+ and K+ ions. The enzyme is
            functionally homologous with EC 3.6.1.35, 3.6.1.37 and 3.6.1.38,
            but not 3.6.1.34. Formerly included with EC 3.6.1.3.
            (EC 3.6.1.35 H+-transporting ATPase)
            (EC 3.6.1.37 Na+/K+-transporting ATPase)
            (EC 3.6.1.38 Ca2+-transporting ATPase)
DISEASE     MIM: 137216  ATPase, H+, K+ transporting, alpha
            MIM: 137217  ATPase, H+, K+ transporting, beta
            MIM: 182360  ATPase, Na+K+ transporting, alpha-1 polypeptide-like
            MIM: 277900  ATPase, Cu++ transporting, beta polypeptide; Wilson
                         disease (3)
            MIM: 300011  ATPase, Cu++ transporting, alpha polypeptide; Menkes
                         disease, 309400 (3); Occipital horn syndrome, 304150
                         (3); Cutis laxa, neonatal (3)
MOTIF       PS: PS00154  D-K-T-G-T-[LIVM]-[TI]
            PS: PS00390  [FYW]-x(2)-[FYW]-x-[FYW]-[DN]-x(6)-[LIVM]-G-R-T-x(3)-W
            PS: PS00391  [RK]-x(2)-C-[RKQW]-x(5)-L-x(2)-C-[SA]-G
            PS: PS01047  [LIVM]-x(3,4)-C-x-[STAGN]-C-x(3)-[LIVMF]-x(3)-[LIVM]-
                         x(3,4)-[GE]-[LIVMAP]-x(3,4)-[IVA]-x-[LIVMFY]
GENES       MJA: MJ1275
            MTH: MTH358
            ECO: b0484(ybaR) b0696(kdpC) b0697(kdpB) b0698(kdpA)
            HPY: HP1072(copA)
            SYN: slr1728(kdpA) slr1729(kdpB) slr1730(kdpC)
            SCE: YBR295W(CCC2)
            HSA: ATP4A(ATP6A) ATP4B(ATP6B)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.6.1.36
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.36
///