ENTRY       EC 3.5.5.1
NAME        Nitrilase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In nitriles
SYSNAME     Nitrile aminohydrolase
REACTION    a Nitrile + H2O = a Carboxylate + NH3
SUBSTRATE   Nitrile
            (Indole-3-yl)acetonitrile
            H2O
            (+/-)-2-(4'-Isobutylphenyl)propionitrile
            Acid amide
PRODUCT     Carboxylate
            NH3
COMMENT     Acts on a wide range of aromatic nitriles including
            (indole-3-yl)acetonitrile, and also on some aliphatic nitriles,
            and on the corresponding acid amides. (cf. EC 4.2.1.84)
PATHWAY     PATH: MAP00380  Tryptophan metabolism
            PATH: MAP00460  Cyanoamino acid metabolism
            PATH: MAP00910  Nitrogen metabolism
MOTIF       PS: PS00920  G-x(2)-[LIVMFY](2)-x-[IF]-x-E-x(2)-[LIVM]-x-G-Y-P
            PS: PS00921  G-[GAQ]-x(2)-C-[WA]-E-[NH]-x(2)-[PST]-[LIVMFYS]-x-[KR]
DBLINKS     University of Geneva ENZYME DATA BANK: 3.5.5.1
            WIT (What Is There) Metabolic Reconstruction: 3.5.5.1
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