ENTRY       EC 3.5.4.9
NAME        Methenyltetrahydrofolate cyclohydrolase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amidines
SYSNAME     5,10-Methenyltetrahydrofolate 5-hydrolase(decyclizing)
REACTION    5,10-Methenyltetrahydrofolate + H2O = 10-Formyltetrahydrofolate
SUBSTRATE   5,10-Methenyltetrahydrofolate
            H2O
PRODUCT     10-Formyltetrahydrofolate
COMMENT     In eucaryotes occurs as a trifunctional enzyme also having
            methylenetetrahydrofolate dehydrogenase(NADP+) (EC 1.5.1.5)
            and formate--tetrahydrofolate ligase (EC 6.3.4.3) activity.
            In some procaryotes occurs as a bifunctional enzyme also
            having dehydrogenase (EC 1.5.1.5) activity or
            formiminotetrahydrofolate cyclodeaminase (EC 4.3.1.4) activity.
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
            PATH: MAP00670  One carbon pool by folate
MOTIF       PS: PS00721  G-[LIVM]-K-G-G-A-A-G-G-G-Y
            PS: PS00722  V-A-T-V-R-A-L-K-x-[HN]-G-G
            PS: PS00766  [EQ]-x-E-[LIVM](2)-x(2)-[LIVM]-x(2)-[LIVM]-N-x-D-x(5)-
                         [LIVMF](3)-Q-L-P-[LV]
            PS: PS00767  P-G-G-V-G-P-[MF]-T-V
GENES       ECO: b0529(folD)
            HIN: HI0609(folD)
            BSU: folD(yqiA)
            MGE: MG013(folD)
            MPN: D12_orf269(folD)
            SCE: YBR084W(MIS1) YGR204W(ADE3)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.5.4.9
            WIT (What Is There) Metabolic Reconstruction: 3.5.4.9
///