ENTRY       EC 3.5.3.1
NAME        Arginase
            Arginine amidinase
            Canavanase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amidines
SYSNAME     L-Arginine amidinohydrolase
REACTION    L-Arginine + H2O = L-Ornithine + Urea
SUBSTRATE   L-Arginine
            alpha-N-Substituted L-arginine
            Canavanine
            H2O
PRODUCT     L-Ornithine
            Urea
COMMENT     Also hydrolyses alpha-N-substituted L-arginines and canavanine.
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
            PATH: MAP00330  Arginine and proline metabolism
DISEASE     MIM: 207800  Arginase, liver; Argininemia (3)
MOTIF       PS: PS00147  [LIVMF]-G-G-x-H-x-[LIVMT]-[STA]-x-[PAG]-x(3)-[GSTA]
            PS: PS00148  [LIVM](2)-x-[LIVMFY]-D-A-H-x-D
            PS: PS01053  [ST]-[LIVMFY]-D-[LIVM]-D-x(3)-[PAQ]-x(3)-P-[GSA]-x(7)-G
GENES       HPY: HP1399(rocF)
            BSU: rocF
            SYN: sll0228
            SCE: YPL111W(CAR1)
            HSA: ARG1(Hs.77600)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.5.3.1
            WIT (What Is There) Metabolic Reconstruction: 3.5.3.1
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