ENTRY       EC 3.5.2.6
NAME        beta-Lactamase
            Penicillinase
            Cephalosporinase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amides
SYSNAME     beta-Lactamhydrolase
REACTION    a beta-Lactam + H2O = a Substituted beta-amino acid
SUBSTRATE   beta-Lactam
            Penicillin
            Cephalosporin
            H2O
PRODUCT     Substituted beta-amino acid
INHIBITOR   m-Carboxyphenyl phenylacetamidomethylphosphonate
COMMENT     A group of enzymes of varing specificity hydrolysing  beta-
            lactams; some act more rapidly on penicillins, some more rapidly
            on cephalosporins. The latter were formerly listed as
            EC 3.5.2.8.
PATHWAY     PATH: MAP00310  Lysine degradation
MOTIF       PS: PS00013  {DERK}(6)-[LIVMFWSTAG](2)-[LIVMFYSTAGCQ]-[AGS]-C
            PS: PS00146  [FY]-x-[LIVMFY]-x-S-[TV]-x-K-x(4)-[AGLM]-x(2)-[LC]
            PS: PS00336  F-E-[LIVM]-G-S-[LIVMG]-[SA]-K
            PS: PS00337  [PA]-x-S-[ST]-F-K-[LIV]-[PAL]-x-[STA]-[LI]
            PS: PS00743  [HN]-x-H-[GSTA]-D-x(2)-G-G-x(7)-G
            PS: PS00744  P-x(3)-[LIVM](2)-x-G-x-C-[LIVM](2)-K
GENES       ECO: b4150(ampC)
            BSU: penP ybxI(ybdS)
            SYN: slr0121 slr0319(blaOXA-3)
STRUCTURES  PDB: 1BLC  1BLH  1BLP  1BLS  1BMC  1BME  1BTL  1DJA  1DJB  1DJC  
                 1KGE  1KGF  1MBL  1PIO  1TEM  1XPB  1ZNB  2BLM  2BLT  3BLM  
                 4BLM  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.5.2.6
            WIT (What Is There) Metabolic Reconstruction: 3.5.2.6
            SCOP (Structural Classificaion of Proteins): 3.5.2.6
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