ENTRY       EC 3.5.1.5
NAME        Urease
            Urea amidohydrolase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     Urea amidohydrolase
REACTION    Urea + H2O = CO2 + 2 NH3
SUBSTRATE   Urea
            H2O
PRODUCT     CO2
            NH3
COFACTOR    Nickel
COMMENT     A nickel protein.  The epsilon-amino residue of Lys is modified
            by reaction with carbon monooxide to form a carbamate group.
            Carbon oxide is required for nickel binding to metal-free urease.
            Two nickel ions bind to ureaase.
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
            PATH: MAP00230  Purine metabolism
MOTIF       PS: PS00145  [LIVM](2)-[CT]-H-[HN]-L-x(3)-[LIVM]-x(2)-D-[LIVM]-x-F-A
            PS: PS01120  T-A-[GA](2)-[LIVM]-D-x-H-[LIVM]-H-x(3)-P
GENES       HIN: HI0539(ureC) HI0540(ureB) HI0541(ureA)
            HPY: HP0072(ureB) HP0073(ureA)
            BSU: ureA ureB ureC
            SYN: sll0420(ureB) sll1750(ureC) slr1256(ureA)
STRUCTURES  PDB: 2KAU  1KRC  1KRB  1KAU  1KRA  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.5.1.5
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.5
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