ENTRY       EC 3.4.99.46
NAME        Multicatalytic endopeptidase complex
            Multicatalytic proteinase (complex)
            Ingensin
            Macropain
            Prosome
            Proteasome
            a component of Lens neutral proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
REACTION    Cleavage at Xaa+ bonds in which Xaa carries a hydrophobic, basic
            or acidic sidechain
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
INHIBITOR   Mercurial reagent
            Inhibitor of serine endopeptidase
COMMENT     A multisubunit protein abundant in the cytoplasm of most
            eukaryotic cells, apparently containing at least three distinct
            endopeptidase active sites. Inhibited by mercurial reagents and
            some inhibitors of serine endopeptidases.  Formerly included in
            EC 3.4.24.5 and 3.4.22.21.
DISEASE     MIM: 176847  Proteosome subunit MECL1
            MIM: 177045  Large multifunctional protease-2 (proteasome-related
                         sequence-2)
            MIM: 177046  Large multifunctional protease-7 (proteasome-related
                         sequence-7)
            MIM: 600306  Proteasome (prosome, macropain) subunit, alpha type, 3
MOTIF       PS: PS00388  [FY]-x(4)-[STNV]-x-[FYW]-S-P-x-G-[RKH]-x(2)-Q-[LIVM]-
                         [DE]-Y-[SAD]-x(2)-[SAG]
            PS: PS00854  [LIVMA]-[GSA]-[LIVMF]-x-[FYLVG]-x(2)-[GSACFY]-
                         [LIVMSTAC](3)-[GAC]-[GSTACV]-[DES]-x(15)-[RK]-x(12,13)-
                         G-x(2)-[GSTA]-D
GENES       MJA: MJ0591 MJ1237
            MTH: MTH1202 MTH686
            SYN: PRE2) slr0630(YPR103W
            SCE: YBL041W(PRS3) YER012W(PRE1) YER094C(PUP3) YFR050C(PRE4)
                 YGL011C(PRS2) YGR135W(PRS5) YGR253C(PUP2) YJL001W(PRE3)
                 YKL181W(PRPS1) YML092C(PRS4) YMR297W(PRC1) YMR314W(PRE5)
                 YOL038W(PRE6) YOR157C(PUP1) YOR362C(PRS1) YPR103W(PRE2)
STRUCTURES  PDB: 1PMA  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.99.46
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.46
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