ENTRY       EC 3.4.24.7
NAME        Interstital collagenase
            Vertebrate collagenase
            Matrix metalloproteinase 1
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of the triple helix of collagen at about three-quaters
            of the lingth of the molecule from the N-terminus, at Gly775+Ile
            in the alpha1(I) chain.  Cleaves synthetic substrates and alpha-
            macroglobulins at bonds where P1' is a hydrophobic residue
SUBSTRATE   Collagen
            H2O
            alpha-Macroglobulin
PRODUCT     Protein
            Peptide
COFACTOR    Zinc
COMMENT     The enzyme takes its name from substrates of the interstitial
            collagen group - type I, II and III, all of which are cleaved in
            the helical domain.  However, alpha-macroglobulins are cleaved
            much more rapidly.  The enzyme is widely distributed in vertebrate
            animals.
DISEASE     MIM: 120353  Matrix metalloproteinase 1 (interstitial collagenase)
MOTIF       PS: PS00024  [LIAT]-x(3)-W-x(2,3)-[PE]-x(2)-[LIVMFY]-[DEQ]-[SA]-
                         [AV]-[LIVMFY]
            PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
            PS: PS00546  P-R-C-[GN]-x-P-[DR]-[LIVSAP]
GENES       HSA: MMP1(CLG)
STRUCTURES  PDB: 1CGE  1MNC  1CGF  1CGL  1FBL  1HFC  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.24.7
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.7
            SCOP (Structural Classificaion of Proteins): 3.4.24.7
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