ENTRY       EC 3.4.24.52
NAME        Trimerelysin I
            Trimeresurus metalloendopeptidase I
            Hemorrhagic proteinase HR1A
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of only two bonds His10+Leu and Ala14+Leu in the insulin
            B chain.
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COFACTOR    Metal
COMMENT     A 60 kDa hemorrhagic endopeptidase of pI 4.4 from the venom of
            the habu snake (Trimeresurus flavoviridis).
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
            PS: PS00427  C-x(2)-G-x-C-C-x-[NQRS]-C-x-[FM]-x(6)-C-[RK]
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.24.52
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.52
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