ENTRY       EC 3.4.24.50
NAME        Bothrolysin
            Bothrops metalloendopeptidase J
            J Protease
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of Gln4+His, Ser9+His and Ala14+Leu of insulin B chain
            and Pro+Phe of angiotensin I.
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COFACTOR    Metal
COMMENT     A 22.5 kDa endopeptidase from the venom of the jararaca snake
            (Bothrops jararaca), insensitive to phosphoramidon at 0.5 mM.
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.24.50
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.50
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