ENTRY       EC 3.4.24.47
NAME        Horrilysin
            Crotalus horridus metalloendopeptidase
            Hemorrhagic proteinase IV
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of only the single bond Ala14+Leu in the insulin B
            chain, Ser12+Leu in the A chain, and Ile+Gly, Pro+Ala, and
            Ser+Trp in melittin.
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COFACTOR    Metal
COMMENT     A 56 kDa hemorrhagic endopeptidase from the venom of the timber
            rattlesnake (Crotalus horridus horridus) that cleaves basement
            membrane, hide powder and fibrinogen.
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.24.47
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.47
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