ENTRY       EC 3.4.24.46
NAME        Adamalysin
            Crotalus adamanteus metalloendopeptidase
            Proteinase I and II
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of Phe1+Val, His5+Leu, His10+Leu, Ala14+Leu,
            Leu15+Tyr, and Tyr16+Leu of insulin B chain.
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COFACTOR    Metal
COMMENT     From the venom of the eastern diamondback rattlesnake (Crotalus
            adamanteus). Two isoenzymes of approx.  24 kDa that inactivate
            alpha1-proteinase inhibitor by single cleavage.
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
STRUCTURES  PDB: 1IAG  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.24.46
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.46
            SCOP (Structural Classificaion of Proteins): 3.4.24.46
///