ENTRY       EC 3.4.24.45
NAME        Atrolysin F
            Crotalus atrox metalloendopeptidase
            Hemorrhagic toxin f
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of Val2+Asn, Gln4+His, Leu6+Cys, His10+Leu, Ala14+Leu
            and Tyr16+Leu bonds in insulin B chain.
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COFACTOR    Metal
COMMENT     A 64 kDa hemorrhagic endopeptidase from the venom of the western
            diamondback rattlesnake (Crotalus atrox) that digests the gamma
            chain of fibrinogen.  Immunologically distinct from EC 3.4.24.1.
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.24.45
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.45
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