ENTRY       EC 3.4.24.42
NAME        Atrolysin C
            Crotalus atrox metalloendopeptidase C
            Hemorrhagic tosin c and d
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of His5+Leu, His10+Leu, Ala14+Leu, Tyr16+Leu and
            Gly23+Phe bonds in B chain of insulin.  With small molecule
            substrates prefers hydrophobic residue at P2' and small residue
            such as Ala, Gly at P1
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
INHIBITOR   Phosphoramidon
COMMENT     A 24 kDa hemorrhagic endopeptidase from the venom of the western
            diamondback rattlesnake (Crotalus atrox) that digests type IV
            collagen, and exists as two forms, c and d.  Phosphoramidon
            inhibits in the 0.1 mM range.  The complete amino acid sequence of
            form d is known.  Hemorrhagic toxin-2 of C. ruber ruber has the
            same Mr and specificity and is a homologue.
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
STRUCTURES  PDB: 1HTD  1DTH  1ATL  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.24.42
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.42
///