ENTRY       EC 3.4.24.40
NAME        Serralysin
            Pseudomonas aeruginosa alkaline proteinase
            Escherichia freundii proteinase
            Serratia marcescens extracellular proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Preferential cleavage of bonds with hydrophobic residues in P'
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     A 50 kDa extracellular endopeptidase from Pseudomonas aeruginosa,
            Escherichia freundii, Serratia marcescens and
            Erwinia chrysanthemi.  There is broad specificity in cleavage of
            the insulin B chain, with some species variations.  The pH optimum
            for digesting various proteins is about 9 - 10.  Formerly included
            in EC 3.4.24.4.
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
            PS: PS00330  D-x-[LI]-x(4)-G-x-D-x-[LI]-x-G-G-x(3)-D
STRUCTURES  PDB: 1SRP  1AKL  1SMP  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.24.40
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.40
            SCOP (Structural Classificaion of Proteins): 3.4.24.40
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