ENTRY       EC 3.4.24.38
NAME        Autolysin
            Chlamydomonas cell wall degrading protease
            Lysin
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of the proline- and hydroxyproline-rich proteins of the
            Chlamydomonas cell wall; also cleaves azocasein, gelatin and
            Leu-Trp-Met+Arg-Phe-Ala.
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
INHIBITOR   Phosphoramidon
COFACTOR    Zinc
COMMENT     A glycoprotein found in the periplasmic space of Chlamydomonas
            reinhardtii gametes in a 62 kDa inactive form; Mr is reduced to
            60 kDa upon activation.  A zinc enzyme, inhibited by
            phosphoramidon, but also thiol-dependent.
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
            PS: PS00546  P-R-C-[GN]-x-P-[DR]-[LIVSAP]
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.24.38
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.38
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