ENTRY       EC 3.4.24.36
NAME        Leishmanolysin
            Promastigote surface endopeptidase
            Glycoprotein gp63
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Preference for hydrophobic residues at P1 and P1' and basic
            residues at P2' and P3'.  A model nonapeptide is cleaved at
            -Ala-Tyr+Leu-Lys-Lys-
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
INHIBITOR   Z-Tyr-Leu-NHOH
COMMENT     A membrane-bound glycoprotein found on the promastigote of various
            species of Leishmania protozoans.  Contains consensus sequence for
            a zine-binding site; Z-Tyr-Leu-NHOH is a strong inhibitor. The
            enzyme can activate its proenzyme by cleavage of the Val100+Val
            bond.  An acid pH optimum is found with certain protein
            substrates.
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.24.36
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.36
///