ENTRY       EC 3.4.24.35
NAME        Gelatinase B
            92-kDa gelatinase
            Matrix metalloproteinase 9
            Type V collagenase
            92-kDa type IV collagenase
            Macrophage gelatinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of gelatin types I and V and collagen type IV and V.
SUBSTRATE   Gelatin type I
            Gelatin type V
            Collagen type IV
            Collagen type V
            H2O
PRODUCT     Peptide
COFACTOR    Metal
COMMENT     Similar to gelatinase A, but possesses a further domain.
DISEASE     MIM: 120361  Matrix metalloproteinase 9 (gelatinase B, 92kD type IV
                         collagenase)
MOTIF       PS: PS00023  C-x(2)-P-F-x-[FYW]-x(7)-C-x(8,10)-W-C-x(4)-[DNS]-[FYW]-
                         x(3,5)-[FYW]-x-[FYW]-C
            PS: PS00024  [LIAT]-x(3)-W-x(2,3)-[PE]-x(2)-[LIVMFY]-[DEQ]-[SA]-
                         [AV]-[LIVMFY]
            PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
            PS: PS00546  P-R-C-[GN]-x-P-[DR]-[LIVSAP]
GENES       HSA: MMP9(CLG4B)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.24.35
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.35
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