ENTRY       EC 3.4.24.34
NAME        Neutrophil collagenase
            Matrix metalloproteinase 8
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of interstitial collagens in the triple helical domain.
            Unlike EC 3.4.24.7, this enzyme cleaves type III collagen more
            slowly than type I
SUBSTRATE   Collagen
            H2O
PRODUCT     Protein
            Peptide
COMMENT     Similar to interstitial gene and highly glycosylated. Stored in
            the specific granules of neutrophil leukocyes. Formerly included
            in EC 3.4.24.7.
DISEASE     MIM: 120355  Matrix metalloproteinase 8 (neutrophil collagenase)
MOTIF       PS: PS00024  [LIAT]-x(3)-W-x(2,3)-[PE]-x(2)-[LIVMFY]-[DEQ]-[SA]-
                         [AV]-[LIVMFY]
            PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
            PS: PS00546  P-R-C-[GN]-x-P-[DR]-[LIVSAP]
GENES       HSA: MMP8(CLG1)
STRUCTURES  PDB: 1JAQ  1JAN  1JAO  1JAP  1MMB  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.24.34
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.34
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