ENTRY       EC 3.4.24.31
NAME        Mycolysin
            Pronase component
            Streptomyces griseus neutral proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Preferential cleavage of bonds with hydrophobic residues in P1'
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
INHIBITOR   Mercaptoacetyl-Phe-Leu
COMMENT     From Streptomyces griseus, S. naraensis, and S. cacaoi.
            Specificity similar to that of thermolysin, but much more
            sensitive to inhibition by mercaptoacetyl-Phe-Leu.  Little
            structural similarity to other bacterial metalloendopeptidases.
            Formerly included in EC 3.4.24.4.
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.24.31
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.31
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