ENTRY       EC 3.4.24.29
NAME        Aurelysin
            Staphylococcus aureus neutral proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of insulin B chain with specificity similar to that of
            thermolysin, preferring hydrophobic P1' residue.  Activates the
            glutamyl endopeptidase (EC 3.4.21.19) of Staphylococcus aureus.
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COFACTOR    Metal
COMMENT     A metalloenzyme from S. aureus earlier confused with
            staphylokinase (a non-enzymatic activator of plasminogen).
            Formerly EC 3.4.99.22 and included in EC 3.4.24.4.
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.24.29
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.29
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