ENTRY       EC 3.4.24.27
NAME        Thermolysin
            Bacillus thermoproteolyticus neutral proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Preferential cleavage: +Leu > + Phe
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     A thermostable extracellular metalloendopeptidase containing four
            calcium ions.  Enzymes that may be species variants of thermolysin
            are reported from Micrococcus caseolyticus and Aspergillus oryzae.
            Formerly included in EC 3.4.24.4.  Closely related but distinct
            enzymes are aeromonolysin, pseudolysin, bacillolysin, aureolysin
            and mycolysin.
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
STRUCTURES  PDB: 2TMN  1LNB  1LND  1HYT  1LNF  1NPC  1THL  1TRL  4TLN  4TMN  
                 5TLN  5TMN  6TMN  7TLN  7TMN  8TLN  1LNA  3TMN  1TMN  1TLP  
                 1LNC  1LNE  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.24.27
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.27
            SCOP (Structural Classificaion of Proteins): 3.4.24.27
///