ENTRY       EC 3.4.24.26
NAME        Pseudolysin
            Pseudomonas elastase
            Pseudomonas aeruginosa neutral metalloproteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Hydrolysis of proteins including elastin, collagen types III and
            IV, fibronectin and immunoglobulin A, generally with bulky
            hydrophobic group at P1'.  Insulin B chain cleavege pattern
            identical to that of thermolysin, but specificity differs in other
            respects
SUBSTRATE   Elastin
            Collagen type III
            Collagen type IV
            Fibronectin
            Immunoglobulin A
            H2O
PRODUCT     Protein
            Peptide
COMMENT     A homologue of thermolysin that causes tissue damage, from the
            pathogenic bacteria Pseudomonas aeruginosa and Legionella
            pneumophila.  Formerly included in EC 3.4.24.4.
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
STRUCTURES  PDB: 1EZM  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.24.26
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.26
            SCOP (Structural Classificaion of Proteins): 3.4.24.26
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