ENTRY       EC 3.4.24.24
NAME        Gelatinase A
            72-kDa Gelatinase
            Matrix metalloproteinase 2
            Type IV collagenase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavege of gelatin type I and collagen types IV, V, VII, X.
            Cleaves the collagen-like sequence Pro-Gln-Gly+Ile-Ala-Gly-Gln
SUBSTRATE   Gelatin type I
            Collagen type IV
            Collagen type V
            Collagen type VII
            Collagen type X
            H2O
PRODUCT     Protein
            Peptide
COMMENT     A secreted endopeptidase homologous with interstitial collagenase,
            but possessing an additional fibronectin-like domain.
DISEASE     MIM: 120360  Matrix metalloproteinase 2 (gelatinase A, 72kD type IV
                         collagenase)
MOTIF       PS: PS00023  C-x(2)-P-F-x-[FYW]-x(7)-C-x(8,10)-W-C-x(4)-[DNS]-[FYW]-
                         x(3,5)-[FYW]-x-[FYW]-C
            PS: PS00024  [LIAT]-x(3)-W-x(2,3)-[PE]-x(2)-[LIVMFY]-[DEQ]-[SA]-
                         [AV]-[LIVMFY]
            PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
            PS: PS00546  P-R-C-[GN]-x-P-[DR]-[LIVSAP]
GENES       HSA: MMP2(CLG4)
STRUCTURES  PDB: 1GEN  1RTG  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.24.24
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.24
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