ENTRY       EC 3.4.24.23
NAME        Matrilysin
            Matrin
            Uterine metalloendopeptidase
            Matrix metalloproteinase 7
            Putative (or punctuated) metalloproteinase-1
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of Ala14+Leu and Tyr16+Leu in B chain of insulin.  No
            action on collagen types I, II, IV, V.  Cleaves gelatin chain
            alpha2(I) > alpha1(I)
SUBSTRATE   Gelatin chain alpha2(I)
            Gelatin chain alpha1(I)
            H2O
            Azocoll
PRODUCT     Protein
            Peptide
COMMENT     Found in rat uterus, the smallest member of the interstitial
            collagenase family (19 kDa).  Similar in specificity to
            stromelysin, but more active on azocoll.
DISEASE     MIM: 178990  Matrix metalloproteinase 7 (matrilysin, uterine)
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
            PS: PS00546  P-R-C-[GN]-x-P-[DR]-[LIVSAP]
GENES       HSA: MMP7(MPSL1)
STRUCTURES  PDB: 1MMR  1MMQ  1MMP  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.24.23
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.23
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