ENTRY       EC 3.4.24.22
NAME        Stromelysin 2
            Matrix metalloproteinase 10
            Transin 2
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Similar to stromelysin 1, but action on collagen types III, IV and
            V is weak
SUBSTRATE   Protein
            Peptide
            H2O
            Proteoglycan
            Fibronectin
            Collagen type III
            Collagen type IV
            Collagen type V
            Collagen type IX
            Procollagenase
            Gelatin type I
            Gelatin type III
            Gelatin type IV
            Gelatin type V
PRODUCT     Protein
            Peptide
            Collagenase
COMMENT     Homologue of interstitial collagenase that digests gelatin types
            I, III, IV, V, fibronectin and proteoglycan.
DISEASE     MIM: 185260  Matrix metalloproteinase 10 (stromelysin 2)
MOTIF       PS: PS00024  [LIAT]-x(3)-W-x(2,3)-[PE]-x(2)-[LIVMFY]-[DEQ]-[SA]-
                         [AV]-[LIVMFY]
            PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
            PS: PS00546  P-R-C-[GN]-x-P-[DR]-[LIVSAP]
GENES       HSA: MMP10(STMY2)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.24.22
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.22
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