ENTRY       EC 3.4.24.19
NAME        Procollagen C-endopeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of the C-terminal propeptide at Ala+Asp in type I and II
            procollagens and at Arg+Asp in type III.
SUBSTRATE   Procollagen
            H2O
PRODUCT     Collagen
            Peptide
COFACTOR    Metal
EFFECTOR    Calcium
COMMENT     An 100 kDa endopeptidase, the activity of which is increased by
            Ca2+ and by an enhancer glycoprotein.
GENES       HSA: PCOLC
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.24.19
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.19
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