ENTRY       EC 3.4.24.18
NAME        Meprin A
            Endopeptidase-2
            Meprin-a
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Hydrolysis of protein and peptide substrates preferentially on
            carboxyl side of hydrophobic residues
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     A membrane-bound metalloendopeptidase of rat and mouse kidney and
            intestinal bruch borders, and salivary ducts.  Differences from
            neprilysin (EC 3.4.24.11) include insensitivity to phosphoramidon
            and thiorphan.  PABA-peptide hydrolase is a very similar enzyme
            found in human intestinal microvilli.  Formerly included in
            EC 3.4.24.11.
DISEASE     MIM: 600388  Meprin A, alpha
            MIM: 600389  Meprin A, beta
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
            PS: PS00740  G-x(12)-G-x(2)-A-x-L-x(4)-[LIVM]-x(6,7)-C-[LIVM]-x-F
GENES       HSA: MEP1A(PPHA) MEP1B
STRUCTURES  PDB: 1IAF  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.24.18
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.18
            SCOP (Structural Classificaion of Proteins): 3.4.24.18
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