ENTRY       EC 3.4.24.17
NAME        Stromelysin 1
            Matrix metalloproteinase 3
            Proteoglycanase
            Collagenase activating protein
            Procollagenase activator
            Transin
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Preferential cleavage where P1', P2' and P3' are hydrophobic
            residues
SUBSTRATE   Protein
            Peptide
            H2O
            Proteoglycan
            Fibronectin
            Collagen type III
            Collagen type IV
            Collagen type V
            Collagen type IX
            Procollagenase
PRODUCT     Protein
            Peptide
            Collagenase
COMMENT     An extracellular endopeptidase of vertebrate tissues homologous
            with interstitial collagenase.  Digests proteoglycan, fibronectin,
            collagen types III, IV, V and IX, and activates procollagenase.
DISEASE     MIM: 185250  Matrix metalloproteinase 3 (stromelysin 1,
                         progelatinase)
MOTIF       PS: PS00024  [LIAT]-x(3)-W-x(2,3)-[PE]-x(2)-[LIVMFY]-[DEQ]-[SA]-
                         [AV]-[LIVMFY]
            PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
            PS: PS00546  P-R-C-[GN]-x-P-[DR]-[LIVSAP]
GENES       HSA: MMP3(STMY)
STRUCTURES  PDB: 1UMS  1UMT  2SRT  1SLN  1SLM  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.24.17
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.17
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