ENTRY       EC 3.4.24.16
NAME        Neurolysin
            Neurotensin endopeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Preferential cleavage in neurotensin: Pro10+Tyr.
SUBSTRATE   Neurotensin
            H2O
            Dynorphin
PRODUCT     Peptide
COFACTOR    Metal
COMMENT     No absolute requirement for a prolyl bond: the enzyme acts on some
            peptides, such as dynorphin 1-8, that do not contain proline, and
            does not act on some others that do.
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.24.16
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.16
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