ENTRY       EC 3.4.24.15
NAME        Thimet oligopeptidase
            Pz-peptidase
            Soluble metalloendopeptidase
            Endo-oligopeptidase A
            Tissue-endopeptidase degrading collagenase-synthetic-substrate
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Preferential cleavage of bonds with hydrophobic residues at P1, P2
            and P3' and a small residue at P1' in substrates of 5-15 residues
SUBSTRATE   Protein
            Peptide
            H2O
            Bradykinin
PRODUCT     Protein
            Peptide
EFFECTOR    Thiol compound
COMMENT     Thiol compounds activate at low concentrations.  Formerly also
            EC 3.4.22.19 and EC 3.4.99.31.
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
GENES       HSA: THOP1 THOP2
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.24.15
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.15
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