ENTRY       EC 3.4.24.14
NAME        Procollagen N-endopeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleaves the N-propeptide of collagen chain alpha1(I) at P1, P2
            and P3' and a small residue at P1' in substrates of 5-15 residues.
SUBSTRATE   Procollagen
            H2O
PRODUCT     Collagen alpha1(I)
            Peptide
COFACTOR    Metal
COMMENT     Removes the propeptides of type I and II collagens prior to fibril
            assembly.  Does not act on type III collagen.
GENES       HSA: PCOLN3
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.24.14
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.14
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