ENTRY       EC 3.4.24.11
NAME        Neprilysin
            Neutral endopeptidase
            Endopeptidase 24.11
            Kidney-brush-border neutral peptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Preferential cleavage of polypeptides between hydrophobic
            residues, particularly with Phe or Tyr at P1'
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
INHIBITOR   EDTA
            Phosphoramidon
            (S)-N-[3-(3,4-Methylenedioxyphenyl)-2-(acetylthio)methyl-1-
            $oxoprolyl]glycine benzyl ester
            (S)-N-[3-(3,4-Methylenedioxyphenyl)-2-(acetylthio)methyl-1-
            $oxoprolyl]-(S)-alanine benzyl ester
            (S)-N-[3-(3,4-Methylenedioxyphenyl)-2-(mercaptomethyl)-1-
            $oxoprolyl]glycine
            (S)-N-[3-(3,4-Methylenedioxyphenyl)-2-(mercaptomethyl)-1-
            $oxoprolyl]-(S)-alanine
            Phosphoramidon
            Thiorphan
COFACTOR    Zinc
COMMENT     A membrane-bound glycoprotein widely distributed in animal
            tissues.  Inhibited by phosphoramidon and thiorphan. Common acute
            lymphoblastic leukemia antigen (CALLA).
DISEASE     MIM: 120520  Membrane metallo-endopeptidase (common acute
                         lymphocytic leukemia
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
GENES       HSA: MME(CD10)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.24.11
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.11
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