ENTRY       EC 3.4.24.1
NAME        Atrolysin A
            Crotalus atrox metalloendopeptidase a
            Hemorrhagic toxin a
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of Asn3+Gln, His5+Leu, His10+Leu, Ala14+Leu and Tyr16+Leu
            in insulin B chain; removes C-terminal Leu from small peptides
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
            L-Leucine
COMMENT     A hemorrhagic endopeptidase of 68 kDa, one of six hemorrhagic
            toxins in the venom of the western diamondback rattlesnake. The
            60 kDa hemorrhagic toxin 1 of C. ruber ruber shows identical
            specificity.  Related metalloendopeptidases from rattlesnake
            venoms are EC 3.4.24.41, 3.4.24.42, 3.4.24.43, 3.4.24.44,
            3.4.24.45, 3.4.24.46, 3.4.24.47 and 3.4.24.48.
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.24.1
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.1
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