ENTRY       EC 3.4.23.5
NAME        Cathepsin D
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Specificity similar to, but narrower than, that of pepsin A
            (Preferential cleavage: hydrophobic, preferably aromatic, residues
            in P1 and P1' positions.  Cleaves Phe1+Val, Gln4+His, Glu13+Ala,
            Ala14+Leu, Leu15+Tyr, Tyr16+Leu, Gly23+Phe, Phe24+Phe and
            Phe25+Tyr bonds in the B chain of insulin.)
            Does not cleave the Gln4-His bond in B chain of insulin
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
INHIBITOR   Methyl 2-diazoacetamidohexonate
COMMENT     Occurs intracellularly, in lysosomes.  A zymogen form is known.
            Formerly EC 3.4.4.23.
DISEASE     MIM: 116840  Cathepsin D (lysosomal aspartyl protease)
MOTIF       PS: PS00141  [LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-
                         [STAPDENQ]-x-[LIVMFSTNC]-x-[LIVMFGTA]
GENES       HSA: CTSD(CPSD) CTSE(Hs.1355)
STRUCTURES  PDB: 1LYB  1LYA  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.23.5
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.5
            SCOP (Structural Classificaion of Proteins): 3.4.23.5
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