ENTRY       EC 3.4.23.31
NAME        Scytalidopepsin A
            Scytalidium aspartic proteinase A
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Preferential cleavage: hydrophobic, preferably aromatic, residues
            in P1 and P1' positions. Cleaves Cys(SO3H)7+Gly and Leu17+Val in
            the B chain of insulin.
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     Isolated from the imperfect fungus Scytalidium lignicolum.  Not
            inhibited by pepstatin-Ac, methyl 2-diazoacetamidohexanoate or
            1,2-epoxy-3-(p-nitrophenyl)propane.  A related enzyme from the
            same organism, proteinase C, is also insensitive to these
            inhibitors and has Mr = 406 kDa.
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.23.31
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.31
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