ENTRY       EC 3.4.23.30
NAME        Pycnoporopepsin
            Proteinase Ia
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Preferential cleavage: hydrophobic, preferably aromatic, residues
            in P1 and P1' positions. Cleaving only three bonds in
            the B chain of insulin: Ala14+Leu, Tyr16+Leu, and Phe24+Phe.
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     From the basidiomycete Pycnoporus sanguineus, formerly known as
            P. coccineus and Trametes sanguinea.  Formerly included in
            EC 3.4.23.6.
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.23.30
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.30
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