ENTRY       EC 3.4.23.3
NAME        Gastricsin
            Pepsin C
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    More restricted specificity than pepsin A, but shows preferential
            cleavage at Tyr+ bonds.  High activity on hemoglobin
SUBSTRATE   Protein
            Peptide
            Hemoglobin
            H2O
PRODUCT     Protein
            Peptide
COMMENT     Formed from progastricsin, apparently in the gastric juice of most
            vertebrates.  In addition to the fundus, progastricsin is also
            secreted in antrum and proximal duodenum.  Seminal plasma contains
            a zymogen that is immunologically identical with progastricsin.
            Formerly EC 3.4.4.22.
DISEASE     MIM: 169740  Preprogastricsin
MOTIF       PS: PS00141  [LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-
                         [STAPDENQ]-x-[LIVMFSTNC]-x-[LIVMFGTA]
GENES       HSA: PGC(Hs.89612)
STRUCTURES  PDB: 1HTR  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.23.3
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.3
            SCOP (Structural Classificaion of Proteins): 3.4.23.3
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