ENTRY       EC 3.4.23.27
NAME        Physaropepsin
            Physarum aspartic proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Milk clotting activity.  Preferential cleavage of Gly8+Ser in B
            chain of insulin most rapidly, followed by Leu11+Val,
            Cys(SO3H)19+Gly and Phe24+Phe.  No action on Ac-Phe-Tyr(I)2.
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
INHIBITOR   Methyl 2-diazoacetamidohexanoate
COMMENT     From the slime mould Physarum polycephalum.  Is not inhibited by
            pepstatin, but is blocked by methyl 2-diazoacetamidohexanoate.
            Closely similar enzymes are found in Dictyostelium discoideum
            and P. Flavicomum.  Formerly included in EC 3.4.23.6.
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.23.27
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.27
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