ENTRY       EC 3.4.23.25
NAME        Saccharopepsin
            Yeast endopeptidase A
            Saccharomyces aspartic proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Hydrolysis of proteins with broad sprcificity for peptide bonds.
            Cleaves -Leu-Leu+Val-Tyr- bond in a synthetic substrate.  Does not
            act on esters of Tyr or Arg
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     Located in the vacuole of the baker's yeast (Saccharomyces
            cerevisiae) cell.  A homologue of pepsin A.  Formerly EC 3.4.23.8,
            and included in EC 3.4.23.6.
MOTIF       PS: PS00141  [LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-
                         [STAPDENQ]-x-[LIVMFSTNC]-x-[LIVMFGTA]
GENES       SCE: YPL154C(PEP4)
STRUCTURES  PDB: 1JXR  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.23.25
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.25
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