ENTRY       EC 3.4.23.22
NAME        Endothiapepsin
            Endothia aspartic proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Hydrolysis of proteins with specificity similar to that of pepsin
            A; prefers hydrophobic residues at P1 and P1', but does not cleave
            Ala14-Leu in the B chain of insulin or Z-Glu-Tyr.  Clots milk
SUBSTRATE   Protein
            Peptide
            Casein
            H2O
PRODUCT     Protein
            Peptide
COMMENT     From the ascomycete Endothia parasitica.  A homologue of pepsin A.
            Formerly EC 3.4.23.10, and included in EC 3.4.23.6.
MOTIF       PS: PS00141  [LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-
                         [STAPDENQ]-x-[LIVMFSTNC]-x-[LIVMFGTA]
STRUCTURES  PDB: 1EPQ  1EPP  1EPO  1EPR  1ENT  1EPN  1EPL  1EED  1EPM  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.23.22
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.22
            SCOP (Structural Classificaion of Proteins): 3.4.23.22
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