ENTRY       EC 3.4.23.21
NAME        Rhizopuspepsin
            Rhizopus aspartic proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Hydrolysis of proteins with broad specificity similar to that of
            pepsin A, preferring hydrophobic residues at P1 and P1'.  Clots
            milk and activates trypsinogen.  Does not cleave Gln4-His, but
            does cleave His10+Leu and Val12+Glu in B chain of insulin
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     From the zygomycete fungus Rhizopus chinensis.  Homologue of
            pepsin A.  A similar endopeptidase is found in R. niveus.
            Formerly EC 3.4.23.9, and included in EC 3.4.23.6.
MOTIF       PS: PS00141  [LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-
                         [STAPDENQ]-x-[LIVMFSTNC]-x-[LIVMFGTA]
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.23.21
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.21
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