ENTRY       EC 3.4.23.20
NAME        Penicillopepsin
            Peptidase A
            Penicillium janthinellum aspartic proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Hydrolysis of proteins with broad specificity similar to that of
            pepsin A, preferring hydrophobic residues at P1 and P1', but also
            cleaving Gly20+Glu in the B chain of insulin.  Clots milk, and
            activates trypsinogen
SUBSTRATE   Protein
            Peptide
            Casein
            Trypsinogen
            H2O
PRODUCT     Protein
            Peptide
            Trypsin
COMMENT     From the imperfect fungus Penicillium janthinellum.  Homologue of
            pepsin A, and similar in structure. Closely related enzymes have
            been isolated from P. roqueforti and P. duponti.
            Formerly EC 3.4.23.7, and included in EC 3.4.23.6.
MOTIF       PS: PS00141  [LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-
                         [STAPDENQ]-x-[LIVMFSTNC]-x-[LIVMFGTA]
STRUCTURES  PDB: 1APT  1APU  1PPK  1APW  1APV  3APP  1PPM  1PPL  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.23.20
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.20
            SCOP (Structural Classificaion of Proteins): 3.4.23.20
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