ENTRY       EC 3.4.23.19
NAME        Aspergillopepsin II
            Proteinase A
            Proctase A
            Aspergillus niger var. macrosporus aspartic proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Preverential cleavage in B chain of insulin: Asn3+Gln, Gly13+Ala,
            Tyr26+Thr.
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     Isolated from Aspergillus niger var. macrsprus, distinct from
            proteinase B (see aspergillopepsin I) in specificity and
            insensitivity to pepstatin, Formerly included in EC 3.4.23.6.
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.23.19
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.19
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