ENTRY       EC 3.4.23.18
NAME        Aspergillopepsin I
            Awamorin
            Aspergillopepsin A
            Aspergillopepsin F
            Proteinase B
            Proctase B
            Trypsinogen kinase
            Aspergillopeptidase A
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Hydrolysis of rpteoins with broad specificity.  Generally favours
            hydrophobic residues in P1 and P1', but also accepts Lys in P1,
            which leads to activation of trypsinogen.  Does not clot milk
SUBSTRATE   Protein
            Peptide
            Trypsinogen
            H2O
PRODUCT     Protein
            Peptide
            Trypsin
COMMENT     Found in a variety of Aspergillus species (imperfect fungi):
            Aspergillus awamori (awamorin, aspergillopepsin A),
            A. foetidus (aspergillopepsin F), A. fumigatus, A. kawachii,
            A. niger (proteinase B, proctase B), A. oryzae (trypsinogen
            kinase), A. saitoi (aspergillopeptidase A), and A. sojae.
            Formerly included in EC 3.4.23.6.
MOTIF       PS: PS00141  [LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-
                         [STAPDENQ]-x-[LIVMFSTNC]-x-[LIVMFGTA]
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.23.18
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.18
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