ENTRY       EC 3.4.23.16
NAME        Retropepsin
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Specific for a P1 residue that is hydrophobic, and P1' variable,
            but often Pro.
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     Active enzyme is a dimer of identical 11kD subunits. Present in
            human immunodeficiency virus (HIV-1), and various leukemia and
            other viruses.
MOTIF       PS: PS00141  [LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-
                         [STAPDENQ]-x-[LIVMFSTNC]-x-[LIVMFGTA]
STRUCTURES  PDB: 7UPJ  1FMB  5UPJ  1BVG  3UPJ  2UPJ  1YTJ  6UPJ  1UPJ  1TCX  
                 1TCW  1PRO  1ODX  1YTI  1YTH  1YTG  1HPO  1ODW  1MTR  1HXB  
                 1FIV  1BVE  4UPJ  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.23.16
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.16
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